The Expression Level Of Growth Hormone Receptor In Rectal Neoplasm Tissue

Objective The expression level of growth hormone receptors (GHR) in rectal neoplasm tissue was investigated comparing to the normal rectal mucosa of the broken ends. Method 43 rectal neoplasm patients who received radical resection of rectal carcinoma were chosen. According to the differentiation level of the tumor tissue, all the cases were divided into 3 groups, which were the well-differentiated group, the moderately differentiated group, and the poorly differentiated group. In each patients, immunohistochemistry was used to demonstrated the GHR expression in the tumor tissue and the normal broken ends. The cells expressing GHR were counted. If GHR were expressed in less than 25% cells, the GHR expressing level was (±). If GHR were expressed in 25%-50% cells, the GHR expressing level was (+). If GHR were expressed in 50%-75% cells, the GHR expressing level was (++). If GHR were expressed in more than 75% cells, the GHR expressing level was (+++). Result The expression level of GHR was positive or higher in all the cases except the broken end of a patient who was classified in the moderately differentiated group. The expression level of GHR in the tumor tissue of the poorly differentiated group was higher than the well-differentiated group (P=0.002) or the moderately differentiated group (P=0. 003). The expression level of GHR in the normal rectal tissue of the well-differentiated group was lower...