Sodium Ferulate Inhabits Tubular Epithelium's Apoptosis From Ischemia-reperfusion-induced ARF

Background and objectivesIschemia-reperfusion-induced renal injury is the most common cause of acute renal failure and is characterized by pronounced depression of the glomerular filtration rates (GFR). Acute renal failure (ARF) affects as many as 5% of all hospitalized patients and has an unacceptably high rate of mortality.Sodium ferulate (SF) , extracted from a traditional Chinese herbal medicine, has recently been reported that ferulic acid protects rat against injury induced by ischemia and reperfusion in brain, liver. These previous reports prompte us to examine whether SF can suppress ischemic injury and the tubular epithelial cells apoptotic death in rat kidney, and find out its signal transduction mechanism. Materials and methodsMale Sprague-Dawley (SD) rats were randomly divided into five groups (n= 5): sham group, IR group, SF group(100 and 200 mg per kg),SOD group. For induction of total ischemia in the kidney, the bilateral renal vessels were occluded for 45 min with vascular clamps, then vascular clamps were...