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Studies On Antipyretic, Analgesic Effects And Its Mechanisms Of Taurocholic Acid

Posted on:2007-01-31Degree:MasterType:Thesis
Country:ChinaCandidate:W L HaoFull Text:PDF
GTID:2144360185950641Subject:Basic veterinary science
Abstract/Summary:PDF Full Text Request
In order to study the antipyretic and analgesic effects and its mechanisms of Taurocholic Acid(TCA), the effects of TCA on the temperature were investigated by bacilli endotoxin, heterologous protein and chemical materials induced-fever methods; the contents of 5-HT, NE, DA and PGE2 in hypothalamus of rats were measured by using Fluoro-spectrophotometry and competed ELISA; the effects of TCA on the pain threshold were investigated by heat, chemistry and mechanical stimulation methods; the analgesic effects were investigated used the drugs which affect the contents of monamine transmitters by heat stimulation method; the contents of PGE2 in the whole brain of rats were measured by using UV-spectrophotometry. The results showed both high and low dosage of TCA significantly decreased the fever temperature of rats induced by bacilli endotoxin, peptone and 2, 4-dinitrophenol, it also decreased the concentration of NE, DA, 5-HT and PGE2 in hypothalamus of rats. Both high and low dosage of TCA had differert depressant effects to the pain reaction induced by heat, chemistry and mechanical stimulation, and TCA marked decreased the contents of PGE2 in the whole brain of rats in these dosage. TCA could significantly inhibit the algesia effect induced by Res, DDC and Prom, and strengthen the analgesic effect induced by Hal, Cpy and L-try, but couldn't influence the pain threshold used with Phen and Prop. TCA has powerful antipyretic effect; its mechanism has relation to decrease the concentration of NE, DA, 5-HT and PGE2 in Hypothalamus of rat. TCA also has powerful analgesic effect; its mechanism has relation to blocke the DA receptor, conjugate with 5-HT2 receptor, and decreased the contents of PGE2 in the whole brain of rats.
Keywords/Search Tags:TCA, Antipyretic, Analgesic, Mechanism
PDF Full Text Request
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