Expression Of Cyclooxygenase-2 (COX-2) In Human Transitional Cell Carcinoma Of The Bladder And Their Relationship With HER-2 And P53

Background and objective:Carcinoma of urinary bladder is the most common malignant tumor of urinary system. Recently the incidence rate of carcinoma of urinary bladder goes up graduately in our country. The main histopathological category of carcinoma of urinary bladder is transitional cell carcinoma, accounting for 90%. The biological behaviors of transitional cell carcinoma of the bladder is multiplicity and changeable, and its main feature is invasion. The transitional cell carcinoma of the bladder is liable to plant and recrudescence. Researching the relationship of the biological behaviors of transitional cell carcinoma of the bladder and many genes can illuminate the change of genes and their expressions in course of the occurrence, development of transitional cell carcinoma of the bladder and the pathogenesy of transitional cell carcinoma of the bladder. The objective of this study was design to investigate the expressions of COX-2, HER-2 and p53 in human transitional cell carcinoma of the bladder and their possible correlations, in order to give theoretical guidance to the diagnosis, therapy, prognosis, and monitoring of the human transitional cell carcinoma of the bladder.Material and method: In this study,fifty-six cases of transitional cell carcinoma of the bladder were selected from patients who had undergone operation in Department of Urology,The First Affilliated Hospital of Guangxi Medical University in the period of years from 2003 to 2005.The diagnosis of all the selected cases had been confirmed through pathological examination and their paraffin embedded blocks were preserved well in the Department of Pathology. The expressions of COX-2, HER-2 and p53 by...