The Study On The Passage Of Heterologous-transplanted Tumor Of Human Stomach In Immune Tolerance Syria Hamsters

Objective: Animal model of human tumor heterotransplantation has become the important tool used in area of human tumor immunology, pathology, pharmacology, pharmacodynamics and acology for it's transplanted tumors have the similar tissue structure, patho-morphous and biological character to the original human tumors and it's sensitivity to chemotherapy drug is similar to clinical therapeutic effect. Now, commonly used method is heterotransplantation of human tumors in immune deficiency (for example, nude mouse) or immune suppression animals (for example, radiation exposure animal with sublethal dose). Growth of transplantation tumor can imitate formation of human tumor, rate of forming-tumor is high, time spending is uniform, size and weight of tumor can facility measured. This model is suitable for preclinical and clinical medicine research. But the host of this model lacks in immunologic function absolutely, so it could be infected easily with microorganism, it's toleration to treatment factors is very bad and it's environment in vivo is completely different with tumor patient's in which immune response is weak only to...