Study On The Function Of P38MAPK In Gastric Carcinoma Cell Line And Its Relationship With COX-2

Objective:Gastric carcinoma (GC) is a disease that greatly threatens the health of our national people, whose incidence rate grows up year by year. The clinical epidemiological investigation and animal trial study show that non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the incidence rate of digestive tract carcinoma. Research indicates that the mechanism of the antineoplastic effect of NSAIDs is tightly related with COX-2 and P38MAPK.Cyclooxygenase (COX-2) is a key enzyme in the process of producing prostaglandin (PG), including at least two isoforms in human: COX-1 and COX-2. Research has revealed that COX-2 has a close relation with carcinoma it is involved in the generating and developing period of carcinoma and is highly expressed in gastroenterology carcinoma.Mitogen-activated protein kinase (MAPK) cascades is an important signal transduction system in cell, involved in its growing, generating, differentiation and apoptosis. Up to now, research have discovered that MAPK includes four subfamilies: stress-activated protein kinase (SAPK), also named C-Jun N-terminal kinase (JNK); extrocellular-signal regulated kinase 2(ERK-2); big MAP kinase 1(BMK1) and P38MAPK. P38MAPK is one of the highlights in the signal transduction...