The Expression Of DcR3 And Caspase-8 In Laryngeal Carcinoma And The Relation Among DcR3 And Caspase-8 And Apoptosis

Objective: The carcinoma of larynx is very common malignant neoplasm in otolaryngology and head and neck surgery. Recent studies have proved that dysregulation of the genes controlling apoptosis may contribute to the process of tumorigenesis by reducing the rate of cell death and allowing the accumulation of other genetic defect. A new member of the tumor necrosis factor receptor (TNFR) superfamily, Decoy receptor 3 (DcR3), can reject the apoptosis as a special inhibitor of apoptosis. Caspase-8 can lead to apoptosis as a promoting apoptosis factor. The high expression of DcR3 and low expression of Caspase-8 may contribute to dysregulation of balance between apoptosis and proliferation as well as lead to tumorigenesis. In our study, Our aim is to investigate the correlation between the expression of DcR3 and Caspase-8 and the development of larynx, also analyzed the relation of DcR3 and Caspase-8 and apoptosis each other. We try to explore genesis mechanism of laryngeal carcinoma at the level of molecular biology.Methods: 41 laryngeal carcinoma fresh samples were analyzed and meanwhile 41 para-carcinoma tissues (to cutting...