Uraemia And Hemodialysis Effect On Cytokines In Plasm

Patients of chronic renal failure have usually serious immune dysfunction. Though some cumulative toxic materials are removed by hemodialysis at the end of renal failure, alleviating some clinical symptoms, patients still have obvious exhibition of low cellular immunity function such as viral susceptibility, high incidence rate of malignant tumors. Cytokines are hormone-like materials related to immunity effect or have immunoregulation function produced by immunological cells or non- immunological cells. They are vital mediators of immunoregulation. If cytokines secrete abnormally, cells in immune system network regulation will unbalance, which lead to immune inflammatory diseases of organism. Peripheral blood mononuclear cells(PBMC) of healthy people have no the gene expression of cytokines, and don't produce cytokines. But during renal failure accumulating toxic materials in organism lead to the activation of PBMC. The ability of kidney to remove cytokines decreases, which leads to the high level of cytokines in blood plasma. Uraemia is the end phase of chronic renal failure, and maintaining hemodialysis is one of means of clinical treatment uraemia at present. Among the acute complications and chronic ones caused by the hemodialysis, the functions of cytokines are more and more attached importance to. The aim of this paper was to investigate the cytokine changes of patients of uraemia and the hemodialysis effect on cytokines and...