Studies On The Role Of MEK As A Costimulating Factor In DC Maturation And MEK-DC Vaccine In Inhibiting Lewis Lung Carcinoma

Dendritic cells (DC) have the strongest capacity in capturing, processing and presenting antigen in imraunocytes. DC can initiate immune responses of T cells and induce T cell-dependent antibodies generation. These functions are much correlated to maturation of DC. In recent years, more and more evidences indicate that cellular immunity especially induced by CTL is important in resisting malignancies. So it becomes the key of this study that how to induce DC with CTL activity maturation in vitro.Methionine enkephalin (MEK) as an antibiotic is usually regarded as an endogenous ligand of morphine receptors in brain. MEK is produced while antigen and mitogen of the special active...