The Fabrication Of A Novel Peripheral Nerve Scaffold And Its Application In Peripheral Nerve Injury

The regeneration and function recovery of peripheral nerve is one of the hottest issues in the field of neuroscience. Its surgical management remains a major challenge for the clinical team. Autologous nerve graft is the golden standard in clinic for the peripheral nerve defects repair. However, variable and functional recovery is rarely complete. The quality of donor grafts may be insufficient to guide and support axonal regeneration, nerve autografting involves sacrificing one or more functioning nerves, and sequelae include loss of sensation, scarring, and possible neuroma formation. In addition, the limited availability of donor tissue represents a severe problem. To avoid these problems, more attention has been focused on the development of substitutes for conventional nerve autograft such as: autologous non-nerve graft, homogeneous nerve graft, et.al. Because of respective limitations, all of these methods have little development potential. Only with surgical technique, it is hard to improve curative effect of peripheral nerve surgery.Over the past ten years, with the development of material science, medical science and molecular biology, more and more kinds of materials have come out. At present, the emphases of nerve repair research shift to nerve regeneration, and using of artifical nerve substitute to promote the regrowth of peripheral nerve.Different with other tissue, extraneous graft of peripheral nerve don't possess the lost or degrade function of defected tissue. It's temporary scaffold to advance nerve regeneration by ues of SCs, neurolemma, neurotrophic factors, and basement membrane.Usually, the fabrication of a novel peripheral nerve scaffold undertakes by simulation of neuromechanism.It has Studied that peripheral nerve scaffold making of sponginess ECM...