Expression Of C-Met, Osteopontin And Their Relation With Stromal Angiogenesis In Human Gastric Carcinoma

Background and ObjectiveGC(Gastric carcinoma) is one of the most common malignant neoplasms in the digestive system.Studies have showed that it is the leading cause of carcinoma death in our country.The main reason for death in patients with GC is invasion and metastasis of carcinoma.What the researchers are much interested in is how to diagnose GC in early stage and to further investigate the mechanisms of invasion and metastasis. The carcinogenesis development and metastasis of GC is a multistep process and is affected by many factors. Recently, people pay more attention to the angiogenesis of the carcinoma. The angiogenesis of carcinoma provides the carcinoma tissue with nourishment and air to exchange. It's also the most direct way that carcinoma metastasizes.c-Met, a protein product of metproto-oncogene, is a tyrosine kinase receptor for the...