| Objective: Intercellular adhesion plays an important role in cell development, differentiation, and carcinogenesis, which determines the polarity of cells and participates in the maintenance of the normal histological structure . To achieve intercellular adhesion, epithelial cells possess various cell junctions, the composition and function of which must be tightly regulated, and that conceivably depend on multiple molecular interactions. E-cadherin and its associated cytoplasmic proteins including α-,β-,γ-catenin belong to classical cell adhesion molecules family ,they play a pivotal role in suppression of cancer invasion and metastasis .Among of these proteins ,β -catenin is a dual-function one , it is not only a member of E-cadherin cell adhesion system ,but also a key signal molecule in the Wnt pathway(the wingless pathway in Drosophila) .The purpose of this study is to evaluate the expression of E-cadherin and α-,β-,γ-catenin in normal colorectal tissue ,colorectal adenomas and colorectal carcinoma and to investigate the role of E-cadherin and α-,β-,γ-catenin in carcinogenesis and progression of colorectal carcinoma ;We examine the relation between their expressions and various clinicopathologic variables and evaluate the relation among the four indexs .Method: Expression of E-cadherin and α-,β-,γ-catenin was examined using immunohistochemical technique in 50 cases of colorectal carcinoma ,20 cases of colorectal adenomas and 15 cases of normal colorectal mucosa . SPSS 10.0 was used to evaluate the statistical significance .
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