The Role Of Abnormal Apoptosis Of Lymphocytes In Idiopathic Thrombocytopenic Purpura

Objective Idiopathic thrombocytopenic purpura (ITP) is the most common hemorrhagic disease in children. According to the course of disease it is divided into two types: AITP and CITP, AITP is more common in children. The origin of the disease is to be elucidated. Recently it was reported that the deficient apoptosis of activated lymphocytes in the peripheral blood might play an important role in the development of the disease.Apoptosis is a physiologic or pathological form of cell death that follows activation of either an intrinsic or extrinsic pathway. The intrinsic cell death pathway is controlled by bcl-2 family members. The extrinsic pathway is controlled by death receptor signaling. These two pathways work together to regulate lymphocytes development and function. Intervention in the controlling of lymphocytes apoptosis might play a part in therapy of ITP. Studies of the controlling of lymphocytes apoptosis would be meaningful.The purpose of this study was to investigate the apoptosis rate of lymphocytes, the positive rate of Bcl-2 protein and Bax protein in lymphocytes of AITP children, and to analyze the relationship between the apoptosis rate of lymphocytes and platelet counts, the relationship between the apoptosis rate of lymphocytes and the positive rate of Bcl-2 protein, the relationship between the apoptosis rate and the positive rate of Bax protein, the relationship between the apoptosis rate of lymphocytes and the Bcl-2/Bax ratio.