Study On The Therapeutic Effects Of Hemoperfusion For Acute Organophosphorus Pesticide Poisoning

Acute organophosphorus pesticide poisoning often occurs in our country. The amount of AOPP patients reachs to several thousand every year. Therapeutic measures against mild and moderate AOPP cases could get good results, but the mortality rate of AOPP patients ingesting a lot of organophosphate pesticide is still high. The therapeutic manners against AOPP include antidote, life support treatment, and decreasing the absorption of toxicant. Up to now, the administration of pralidoxime and atropine is already performed well, and life support treatment also shows a preferable look by cardiac pulmonary cerebral resuscitation. Gastric lavage and blood purification such as hemoperfusion have been used to decrease the absorption of toxicant. However, the curative effect of hemoperfusion, as an extracorporeal poison-eliminated technology, is disputed. Hemoperfusion can efficiently remove the amount of toxicant, which is mainly distributed in blood and has a small volume of distribution (Vd < 1.0L/Kg). To some organophosphate pesticide with high adipose-solubility, their volume of distribution is larger than that of blood in body. Although activated charcoal can remove the toxicant from blood in vitro, witch doesn't indicate it can eliminate the total body burden of toxicant. This study is expected to evaluate the efficiency of hemoperfusion by animal models poisoned by parathionTen mongrels poisoned by parathion were randomly divided into HP group and control group. The dogs in HP group were hemoperfused for 2 hours. The clinical effects of hemoperfusion are evaluated by comparison of toxicant concentrations...