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Effects Of Medicines And Early Diagnosis Of Parkinson's Disease

Posted on:2007-08-07Degree:MasterType:Thesis
Country:ChinaCandidate:J P FanFull Text:PDF
GTID:2144360185983376Subject:Neurology
Abstract/Summary:PDF Full Text Request
Objective: Parkinson' s disease (PD) is the main neurodegenerative disorder that influences the middle age and old peoples, its cause is still not clear. Therefore, there isn' t treatment measure aiming at the cause of disease currently. As the most valid medicine, levodopa can alleviate symptom simply, and can' t obstruct and decelerate the progress of PD, contrarily levodopa can accelerate apoptosis and putrescence of dopamine neurons. Therefore, exploring the etiology and valid medicine can exaltate mankind' s health level significantly.PD is chronic and progressive neurodegenerative disease, which is diagnosed mainly depending on the clinic performance without particularity. Thus, the effective rate of diagnosis is about 75%-80%, and while clinical symptom appears, death of dopamine neurons have exceeded 80%. Moreover, put forward with the research of nerve nourishment factor along with the neuroprotective strategy, the patients of PD need more and more to be examined and given neuroprotective treatment in early days. It is important to improve the patient' s prognosis and the living quality.In this study, we injected 6-OHDA into the right striatum of rat to prepare the hemilateral model of PD. Behavior, immunohistochemical...
Keywords/Search Tags:Parkinson' s disease, Immunology, Apoptosis, Dopamine transporter, Lymphocytes in peripheral blood
PDF Full Text Request
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