The Relation Between Genetic Polymorphism Of Cytochrome CYP2C19(P4502C19) And Susceptibility To Esophageal Cancer

ObjectiveThe study intended to investigate the association between genetic polymorphisms of cyp2c19 and susceptibility to esophageal cancer(EC), and the gene-environmental interaction in etiology of esophageal cancer.Materials & methodsUsing 1:2 matched case-control study, we have identified 234 EC patients with endoscopy and pathology diagnosis from Anxi hospital during the periods. A total of 468 controls without history of malignant tumor or digestive system diseases were selected during the same period as cases and matched to each case by gender, age, nationality and inhabited areas.The constructed questionnaires were administered, and the geneotyping of cyp2c19 in 127 EC patients and 254 controls were examined with PCR and PCR-RFLP analysis. Conditional logistic regression was used to analyze the role of environmental factors, gene, gene-environmental in the progress of EC, and to calculate odds ratios and 95% confidence intervals. All the calculations and statistics were performed with the computer program, SPSS Version 12.0.Results1. The frequencies of CYP2C19 wt/wt,wt/m1,wt/m2,m1/m1,and m1/m2 genotype were 15.7%,58.3%,3.1%,19.7%,3.1%,which had statistically significant difference compared with the control group. The distribution of wild-type homozygote (wt/wt),heterozygote(wt/m1,wt/m2)and mutant homozygote(m1/m1,m1/m2)in EC and controls were significant difference(χ2=15.618, P<0.001), CYP2C19 heterozygote and mutant homozygote had a significant increased risk of EC (OR=3.106, 95%CI: 1.636-5.898; OR=4.754, 95%CI: 2.190 -10.320) compared to wild-type homozygote.