Expression Of Cardiomyocyte Angiotensin Ⅱ Receptors And Effects Of Candesartan In The Rat With Pressure Overload-Induced Left Ventricular Hypertrophy

Backgroud and object:The renin-angiotensin system(RAS)plays a key role in the process of left ventricular remodeling of cardiovascular diseases as well as angiotensinâ…¡(Angâ…¡)is the most important effctor peptide of RAS.The biological effects of Angâ…¡are exerted through binding with its specific receptors—angiotensinâ…¡type 1 recepto(rAT₁)and angiotensinâ…¡type 2 recepto(rAT₂).It is generally accepted that most of the biological effects of Angâ…¡in the cardiovascular system are mediated via the AT₁.Although it is believed by many that the physiological role of the AT₂ is to antagonize the effects of AT₁,much more controversial is the resulting function of the AT₂ in the cardiovascular system. Left ventricular hypertrophy (LVH)induced by hypertension is a powerful,independent predictor of cardiovascular morbidity and mortality;and is an independent risk factor of cardiovascular diseases complication , including coronary heart disease,myocardial infarction,stroke and heart failure. This study focused on expression of cardiomyocyte Angâ…¡type receptor,...