Curcumin Anti-proliferatation Of Nasopharyngeal Carcinoma NCE Cells And Apoptosis-induction Mechanism

Purpose and background of the studyNasopharyngeal carcinoma (NPC) is the commonest malignant carcinoma of head and neck with high mortality in Southern China. Most of NPC patients are about 40-50 of age. Conventional radiotherapy is applied only to the early-stage of NPC. However most patients are always diagnosed at the III or IV advanced stage. Chemo-radiotherapy is generally preferable to intermediate and advanced NPC or recrudescent cases. Therefore a combination of DDP and 5—FU is often adopted to treat patients with head and neck carcinoma. But very often most patients could not tolerate such intensive chemotherapy because of their ages and the disease features.Curcumin is a phenolic compound isolated from the rhizome of the plant Curcuma longa. It has been reported to possess anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory properties with little toxicity and low cost. So it is always considered as a potential chemo-prevention of cancer of the third generation. More and more researchers have devoted close attention to it. However, there are few reports about the effects of curcumin on NPC cells, both home and abroad. The present research is to study the curcumin anti-proliferatation of NPC cell line (NCE cells) and the mechanism of apoptosis-induction. The data may provide an experimental basis for the clinical application of curcumin to NPC. Methods1. The anti-proliferative effects of curcumin on NCE cells. The proliferative...