Study On Differentiation From BMSCs Into Dopaminergic Neurons Induced By GDNF And IL-1 α In Vitro

BackgroundParkinson's disease(PD), is a degeneration disease of the central neural system with high morbidity in the elders. The selective degeneration, death and depletion of the dopamine (DA) energetic neurons in the compact part of substantia nigra of midbrain throw light on the pathology of PD. The disorder of the function of basal nuclei with deficient DA in corpora striata caused by the remnant DA neurons' decreasing capability of DA generation contributes to the disease. PD has four essential characteristics, static tremor, rigidity, bradykinesia and postural unsteadiness.The distribution of dopaminergic neurons are on substantia nigra and striatum. Parkinson's disease and dementia praecox, Tourette or hyperkinetic syndrome account for transmitter defilade .The derangement of regulating function at basal ganglia make troubles to the control of DA trmitter with mutilsymptom presentation. Single dopaminergic neurons pathology change of PD is its basis on replacement.BMSCs-derived dopaminergic neurons is the only way out on treatment of PD.The makers of dopaminergic neurons are tyrosine hydroxylase, DA transmitter...