The Rat's Neural Stem Cells Derived From Bone Marrow Stromal Cells Definited Induced And Differentiaed Into Dopaminergic Neuron

1. OverviewParkinson Disease (PD) is a degenerative disease of the central nervous system common in middle-aged old people characterized by progressive deficiency of dopaminergic neurons in nigrostriatal area, with characteristics of tremor, myotonia and hypokinesia. The pathological changes are characterized by deficiency of dopaminergic neurons in substantia nigra compacta and formation of Lewy body (LB) in neurons. The overall incidence is about 0.1%, while the incidence in population over 65 years is 1%. With the aging of society, the incidence and disabling rate of Parkinson Disease tends to increase. Recent studies have found that orphan nuclear related receptor 1 ( Nurr1) gene plays an important role in the development and survival of mesencephalic dopaminergic neurons, therefore, many studies on relations between Nurrl and development of dopaminergic neurons as well as occurrence of Parkinson Disease have been carried out.Nurrl is a transcriptional activation factor of exogenous TH of neural progenitor cells and dopamine transporter. Nurrl is the key factor in inducing progenitor cells of the central nervous system in each developmental stage and area to differentiate into dopaminergic neurons. Deficiency of Nurrl decisively changes the normal development of mesencephalic dopaminergic neurons, resulting in the loss of dopamine specific marker and deficiency of dopamine transmitter, and precursor cells' arrest of development, failure of differentiation into normal dopamine cells or gradual apoptosis in development process. The polymorphism of Nurrl gene may be...