| In our searching for bioactive agents from the sea by MTT method, About 180 fungi strains were collected from the seacoast of Philippine , Cytotoxic screening of the extracts of their mycelia presented 97F49 marine fungi exhibiting potent cytotoxic activities. The broth of 97F49 was isolated by silica gel, Sephadex LH-20, ODS and RP-HPLC chromatographies, fifteen compounds were isolated, and their structures were identified by spectral methods. Of which four are novel Compounds.novel Compounds' structures:1'R~*,2'S~*,6'S~*,8'S~*,8'aR~*-1-(2',8'-dihydroxy-1',2',6'-trimethyl-1',2',6',7',8',8'a-hexahydronaphth alen-1-yl)-3-methoxyl-1-propanone (8); 8-hydroxy-4-methyl-4-Nonen (9);1-methyl-2,6-naphthalene -dicarboxylic acid (10); 7-(2'-hydro)-ethyl-3,4-dihydro-4,8-dihydyoxy-6-methoxyl-1(2H)-Naphthalenone (12).knewn Compounds' structures:22E-Ergosta-5,7,22-trien-3β-ol (1); 22E-5α,8α-Epidioxyergosta-6,22-dien-3β-ol (2) ; 22E-Ergosta-7,22-dien-3β,5β,6β-triol (3);1,6,8-trihydroxy-3-methyl-anthraquinone (4) ; 1,6,8-trihydroxy-3-( 1'- hydro )-methyl-anthraquinone (5); 2,3,4a,8,9,10,10a,10b-octahydroxy-4a, 8,10b-trimethyl-1-H-Naphatho[2,1-b]pyran (6); 1'R~*,2'S~*,6'S~*,8'S~*,8'aR~*-1-(2,8-dihydroxy-1,2,6-trimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3-hydroxy-1-propanone, (7); Modiolide (11); N-2'-Hydroxyoctadec-3-enoyl-1-β-D-glucopyranosyl (13); D-arabitol (14); D-mannitol (15) .
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