The Expression Of ABCG2 And CD₁₃₃ And Their Significance In Human Glioma

Objective: To observe the expression and distribution of ABCG2 and CD₁₃₃ in human glioma and investigate their correlations with clinicopathological features of glioma.Methods: The expression of ABCG2 and CD₁₃₃ were investigated by immunohistochemical staining in 59 surgical specimens of human brain glioma and 5 normal brain tissue. These specimens were also stained by HE to obtain the total number of tumor cells and classificate the gliomas.Results: (1) There were no expression in normal brain tissue. (2) ABCG2 and CD₁₃₃ positive cells were observed in all glioma specimens. Respectivly , the differences of positive cell rates of ABCG2 or CD₁₃₃ in different pathological grades were statistically siginificant (p<0.05),the higher pathological grades have higher positive cell rates . ( 3 ) There were siginificant difference between the positive cell rates of ABCG2 group and CD₁₃₃ group (p<0. 05). The expressions of ABCG2 group were lower than CD₁₃₃ group. There was a siginificant correlation between ABCG2 group and CD₁₃₃ group (r=0. 765, p<0. 01). (4) The differences of positive cell rates in different age groups , not sex and location groups, were statistically siginificant (p<0.05).The elder groups have higher positive cell rates.Conclusions: (1) ABCG2 and CD₁₃₃ did not expressed in normal brain tissue. (2) The differences of positive cell rates in different pathological grades were statistically siginificant , it revealed the positive expression of ABCG2 and...