The Study Of Application Of The Electroencephalography For Evaluation Of Therapeutic Effects Of The Stereotactic Gamma-Knife Radiosurgery On The Rhesus Monkeys With Morphine-dependence

[ Objective ] The purpose of this study was to study the Electroencephalography (EEG) and Brain electrical activity mapping (BEAP) changes of the Rhesus monkeys with morphine-dependence, and changes of EEG and BEAP after the treatment of the Stereotactic Gamma-knife Radiosurgery (GKRS) for the Rhesus monkeys with morphine-dependence, and to evaluate the therapeutic effects of treatment of GKRS for morphine-dependence according to changes of EEG .and BEAP.[Methods] Three healthy aged Rhesus monkeys (Macaca mulatta) (Body weight: 4～5. 5kg ) were grouped randomly into 2 groups, the controlled group (n=1, including monkey3), in which the morphine-dependent monkey was withdrawn from morphine administration after morphine-dependence ; the treated group (n=2, including monkey1 , monkey2), in which the morphine-dependent monkeys were treated by GKRS after morphine-dependence, the targets are bilateral nucleus accumbens (NAC) . The animal model of the Rhesus monkeys with morphine-dependence was established according to the "Dosage-increasing"...