| Objective: To evaluate the method and clinical effect of rotating Gamma-Knife system on brain metastases. Method: Retrospecteded 315 brain metastases patients who had accepted therapies of rotating Gamma-Knife system in the neurosurgry nuit and Gamma-Knife center of The Second Houspital of Shanxi Medical University from June 1997 to May 2003. 301 of them were followed up. A solitary lesion developed in 89 patients and multiple lesions developed in 226 patients.The summary of lesions was 849. The patients were treated with the mean prescription of 14.3Gy (range,10-22Gy) to the 42.98% (range,30%-60%) mean isodose line.The maximam dose in the target core was 39.5Gy(range,17-50Gy).Result: In this paper, there were 301 patients accepted clinical follow-up examination, and 277 of them acquired MRI scan examinations. After the Gamma-Knife treatment, the follow-up MRI scans showed that 48.7% cases completedly relieved (135 of 277 cases), 29.2% cases partly relieved (81 of 277 cases), 15% cases appeared no apparently change(44 of 277 cases), and 6% (17 of 277 cases) continued growing. The local tumore control rate is 94%. In the other side, 88.4% of the patients experienced either improved or stable neurological symptoms before death or at the last time of follow-up. The survival rate matched or exceeded those had been previously reported for surgery and other forms of radiotherapy .Conclusion: Gamma knife radiosurgery seems to be a safe, noninvasive, palliative and effective therapy on brain metastacis.
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