Effects Of Shear Stress On Expression Of Tissue Plasminogen Activator (tPA) And Plasminogen Activator Inhibitor-1 (PAI-1) Of Rat Kidney Proximal Tubular Epithelial Cells Cultured In High Glucose And Its Significance

BACKGROUND AND OBJECTIVE: Cytobiologic alterations resulting from flow- induced shear stress is a growing field of research in many cell types. Previous studies such as vascular endothelial have focused on the potent role of flow in regulating vascular endothelial cell functions by modulation of shear stress applied to the cells. Kidney cells in vivo, especially renal proximal tubular cells also experience a shear stress environment. studies demonstrated that after 5/6 subtotal nephrectomy in the remaining nephron increased tubular flow-induced shear stress increasing could modify the phenotype of proximal tubular cells and could be involved in the modification of ECM remodeling. On the basis of these observations, we hypothesized that the increase in GFR in the early stage of DN resulted initially in a similar increase in the linear velocity of the proximal tubular and induced shear stress increasing in proximal tubular...