| It would be injured if myocardium is suffered from ischemia for long time. Ischemia-reperfusion itself would aggravate the damage of myocardium, although early reperfusion can save some ischemic myocardium. So it is necessary for us to take measures to prevent the ischemia-reperfusion injury. Recently, more and more studies are focus on exploring the endogenous agent in the heart for cardioprotection. It is established that HSP70 acting as a chaperone is protective against ischemia-reperfusion-induced injury in the heart. There is therefore, significant interest in inducing HSP70 as a cytoprotective therapeutic agent in ischemic heart disease of human. Previous studies have demonstrated that puerarin can induce the overexpression of HSP70 in the brain of the rat and that the induction of HSP70 confers a protective effect against ischemia/reperfusion(I/R) injury. No previous study has investigated whether puerarin can induce the expression of HSP70 on the myocardial I/R in rats.Objective: The aim of this study is to : (1)observe the change of HSP70 in myocardium after ischemia-perfusion; (2) observe the effect of puerarin on the expression of HSP70 on the myocardial I/R in rats; (3) observe the protection of puerarin targeting the inflammatory injury of myocardium after ischemia-perfusion in rats in order to explore a new way of myocardial preservation.
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