| [Objective]To study the clinic effects of calcitonin and oral calcium with vitamin D on the osteoporotic fracture of the hip among the postmenopausal women, and the change of the bone metabolism and bone mineral density (BMP), to explore the better process for improving the heal of the osteoporotic fractures.[Methods]This is a 26 weeks, single-centered, prospective and randomized studying. All 60 female patients were randomly allocated into two groups according the time them enter the trial. Group A: calcitonin, vitamin D and calcium; Group B: vitamin D and calcium. All the patients were treated by the same group doctors. Patients of group A received the salmon calcitonin (200IU/day), oral calcium carbonate (600 mg/day) and vitamin D(200 IU); group B received the oral calcium carbonate(600 mg/day ) and vitamin D(200 IU). The markers include osteocalcin, serum alkaline phosphatase, BMD and Harris scores of the hip before and after treatment of all the patients were recorded.[Results]After 26-weeks treatment, 29 patients of calcitonin + calcium group and 28 patients of calcium group were followed-up. In calcitonin + calcium group, the level of serum AKP and BGP decreased ,the lumber spine (L2～4) BMP increased 5.5% (P< 0.05 ) . The level of serum AKP and BGP was not significantly change in the control group. The BMP was decreased significantly in the Wards region. The Harris scores of hip is 85±16 in the calcitonin + calcium group, and70±18 in the control group. (P...
|
PDF Full Text Request