Changes Of 25-hydroxyvitamin D₃-lalphahy-droxylase And Markers Else By Two Type Of Salmon Calcitonin Treatment In Postmenopausal Osteoporosis

Object To explore changes of 1,25(OH)2D3 concentrations and correlative markers and curative effect of bone pain in postmenopausal osteoporosis by salmon caicitonin treatment. Meths To cellect 58 postmenopausal women- 38 postmenopausal osteoporosis and 20 normal bone mineral density(BMD) postmenopausal women in the trial. All cases were subdivided into groups A,B and C. In group A,16 patients were taken nasal spray salmon caicitonin. In group B,22 patients were injected salmon caicitonin. And in the two groups,they were taken elementary caicitonin (3 times per day,1.95g/d). In group C,20 normal bone mineral density postmenopausal women as control group without salmon caicitonin were taken only elementary caicitonin (3 times per day,1.95g/d). To determine the 1,25(OH>2D3 concentrations were checked. The data were studied with analysis of variance,t test,correlation and multiple stepwise regression respectively. Results as a results,the 1,25(OH)2D3 concentrations in postmenopausal osteoporosis(36.18+12.6) were lower than normal postmenopausal women of the same age (42.92 +13.39,P=0.063) and a significant increase of the 25-hydroxyvitamin D3-lalphahydroxylase concentrations was observed in groups A and B after salmon treatment(P<0.01 ),There was a significant decline in urinary deoxypyridinoline (DPDXP<0.001) too. 1,25(OH)2D3 was no correlation with spinal bone mineral density and negative correlation with urinary DPD/Cr levels (correlations -0.221) and bone pain were alleviated or disappeared by salmon treatment in group Aand B. Compared with two type of salmon calcitonin treatment,all markers of our study and bone pain by before and after in postmenopausal osteoporosis were no difference in statistics. Conclusion 1,25 (OH)2D3 concentrations and HMD were significantly increased and bone pain were alleviated or disappeared in postmenopausal osteoporosis by salmon calcitonin treatment. Compared with two type of salmon calcitonin treatment,there was no difference on all marks of our study in statistics.Our study showed 1,25(OH)2D3 may be a routine biochemical marker of bone metabolize,the study offer a new diagnose reference for further research in PMO early.