The Application Of ～1H-MRS In The Diagnosis And Grading Of Gliomas

Objective To evaluate the findings of ~1H-MRS and clinical significance of ~1H-MRS, and to explore the correlation between the findings of ~1H-MRS and the pathological grading of gliomas.Materials and Methods 38 patients of gliomas approved by pathology were reviewed, all cases were categorized into two groups(Low grade gliomas and High grade gliomas)according to WHO diagnostic criteria. The 38 patients were underwent ~1H-MRS before surgery on plain MRI scan. Multiple voxel Proton magnetic resonance spectroscopy was performed on a 1.5T MR scanner using point resolved selective spectroscopy(PRESS), the variety of metabolite peaks were detected in diferent areas.Results The findings of ~1H-MRS: slightly decreased Cr, distinctly decreased NAA and distinctly increased Cho in gliomas. Significant differences between Low / high grade gliomas and normal tissue in Contralateral brain hemispheres were found in the ratios of NAA / Cr, Cho / Cr and NAA / Cho(P<0.01), Significant diferences between Low grade gliomas and High grade gliomas were found in the ratios of NAA / Cr, Cho / Cr and NAA / Cho(P<0. 05), There was significant correlation between the ratios of NAA / Cr, Cho / Cr and NAA / Cho and the pathological grading of gliomas.Conclusion The combination of ~1H-MRS and MRI improves preoperative diagnostic accuracy of gliomas, ~1H-MRS has made it possible to evaluate the grade of gliomas, obtain metabolic information of gliomas and reflect the potential growth of tumor.