The Effect Of XingNaoJieYu Capsule Regulating Expression Of BDNF And NGF In Brain Of Experimental PSD Rat

Objective:After the discussion apoplexy the depression pathogenesis, research the effect of XingNaoJieYu Capsule regulating expression of BDNF and NGF in brain of experimental PSD rat, after expounded XingNaoJieyu Capsule treatment apoplexy the possible depression mechanism.Method:Feeds a week after 60 SD big mouse compatibility, carries on opens box experiment behavior study screening, stochastically carries on the integral close big mouse the grouping, divides into 6 groups, each group of 10, respectively be blank control group, model control group, Fluoxetine Hydrochloride Pulvules group, XingNaoJieYu Capsule large dose group, XingNaoJieYu Capsule the monitoring team, XingNaoJieYu Capsule small monitoring team. Besides the blank group carries on the apoplexy, the depression model duplication. After makes the mold to succeed groups treats 28day, observes the big mouse spontaneous behavior ,the syrup consumption and the weiht; Then takes the brain organization to measure the expression of BDNF and NGF in brain.Result:XingNaoJieYu Capsule large, medium and small monitoring team and Fluoxetine Hydrochloride Pulvules group can increase in the PSD big mouse brain the expression of BDNF and NGF, the weiht and the syrup consumption; Improves the spontaneous behavior study (P<0.05 or P<0.01). XingNaoJieYu Capsule large dose group to elevate the degree obviously to surpass Fluoxetine Hydrochloride Pulvules group (P<0.05). Awakes in the brain solution strongly fragrant capsule the monitoring team not to have the remarkable difference with Fluoxetine Hydrochloride Pulvules group (P>0.05). XingNaoJieYu Capsule to be big, the middle monitoring team elevates the degree obviously to surpass the small monitoring team (P<0.05).Conclusion:XingNaoJieYu Capsule to treat the PSD possible mechanism is through increase in the PSD big mouse brain the expression of BDNF and NGF to improve the patient despondent symptom, and the weight chang which the depression causes after the apoplexy has the distinct improvement function.