Hot Manicol Is Added To Transfusion Affect Nerve Function Resuming And Kidney Function

The Condition inside and outside the organic body may somewhat change following on the cervical spinal cord injury. For example, the turbulance of Ca2+ lead to the increase of patients urinary concretion in number. According to some foreign documents, bladder concretion is often main syndrome of the cervical spinal cord injury with a mortality rate of 45%; the lack of oxygen in tissues produces overmuch free radical and accumulation of lactic acid, killing cells, secreting prostate incretion, and piling up blood platelet, consequently affecting the normal function of kidneys. It is found in some research that diabetes insipidus or oliguria usually come along with trauma on the cervical spinal cord, which are ascribed to the eurhythmic secretion of ADH; The treatment of neurogenic bladder requires a therapy of urethral catheterization , which increases the chance for infections of urologic system..Manicol, a common medicine of dehydration for clinic use, can not only alleviate the dropsy of spinal cord, but also purge free radical. In recent years, people has been aware of its side-effects, especially the acute kidney failure caused by infiltrative illnesses of kidneys, raising mortality rate. The current preventive measures are as follows: be careful about the dose of manicol; control transfusion speed at 10/min, and frequently watch BUN,CREA,uria routine, and OP,etc.Clinically, hot manicol is added to transfusion preventing liquid from crystallizing, reducing the number of liquid particles, and dropping the incidence of phlebitis. However, whether the addition of hot manicol can relieve kidney toxicity or not hasn't been as yet reported in any documents. We therefore design the following experiment that 20 patients of the cervical spinal cord are ranked as A, B, C, d, four groups of subjects, in line with ASIA. And then select paring from the subjects to form the contrasting group and the testing group. The former are transfused with common manical, while the latter with heated manical of 35-37 co. The time span for observation is 7 days. Given the same dose and time of transfusion, test the thickness of Na+ of either group before transfusion, and the sencond day, the 5th day and the 7th day after transfusion; test the thinness of BUN and CREA before and after transfusion and compare the recovery of neuro-system as well(ASIA-MS); make statistical analysis of these data on the criteria of .Based on the analysis, we come to the following conclusions: Na+ of either group drops to some degree and there is no obvious difference in dropping between two groups during the first 5 days(P>0.05). In the left 2 days, the difference grows obvious(P<0.01). It is the same case with the thickness of CREA and BUN(P<0.05), but the recovery of neuro-function appears no different(P>0.05). Finally, the heated manical is able to reduce hyponatremia caused by the cervical spinal cord, and won't decrease its therapeutic effect. Thus it is worthwhile to be promoted for more widely use.