The Study On Relationship Of TCM Symptom Type And Clinical Index In IgA Nephropathy Patients

ObjectiveTo study the relationship between the differentiation syndromes of traditional Chinese medicine and its clinical index in IgA nephropathy (IgAN)。Methods73 cases of IgAN were analyzed prospectively, syndrome different- iations were concluded by the diagnosis criteria of TCM syndrome in the clinic research and guiding principle of the current new herb in chronic nephritis in 2002 into qi deficiency syndrome of spleen and kidney, yin deficiency syndrome of liver and kidney, qi and yin deficiency syndrome, yan deficiency syndrome of spleen and kidney and the accompanied syndrome as affection of exogenous, damp—heat, blood stagnation and turbid damp. The relationship among clinical manifestation, laboratory exami- nation, pathological diagnosis and the above syndromes were observed.ResultsCompared the four clinical syndromes of qi deficiency syndrome of spleen and kidney, yindeficiency syndrome of liver andkidney, qi andyin deficiency syndrome and yan deficiency syndrome of spleen and kidney of 73 cases of patients, the hematuria example number has no difference; Occurrence of large amount of albuminuria gives first place to yan deficiency syndrome of spleen and kidney, has notable difference; Hyper- tension happened in four types comparatively, the dropsy example number has no notable difference; Compared the four clinical syndromes of qi deficiency syndrome of spleen and kidney, yin deficiency syndrome of liver and kidney, qi and yin deficiency syndrome and yan deficiency syndrome of spleen and kidney, the blood creatinine level and the 24 hour urine protein level gradually advances, the blood albumin level gradually reduces; The qi deficiency syndrome of spleen and kidney mostly concurrently has affection of exogenous, yin deficiency syndrome of liver and kidney mostly concurrently has damp—heat, qi and yin deficiency syndrome mostly concurrently has blood stagnation and yan deficiency syndrome of spleen and kidney mostly concurrently has turbid damp. Along with qi deficiency syndrome of spleen and kidney, yin deficiency syndrome of liver and kidney to qi and yin deficiency syndrome, then to yan deficiency syndrome of spleen and kidney, the pathology graduation has the tendency which gradually aggravates; Along with the change of the affection of exogenous, damp-heat, blood stagnation and turbid damp, the pathology graduation has the tendency which gradually aggravates; The albuminuria and the hypertension proportion in renal inadequacy time group is higher than in the renal function normal time group, its has significant difference. The hematuria and the edema proportion compared in two groups do not have the significant difference; The yan deficiency syndrome of spleen and kidney and turbid damp in the renal inadequacy time group have the higher proportion than in the renal function normal time group, which has significant difference.ConclusionDisease character of IgiN were mostly asthenia in origin and sthenia in superficiality; asthenia in origin was qi deficiency syndrome of spleen and kidney, yin deficiency syndrome of liver and kidney and qi and yin deficiency syndrome; sthenia in superficiality was affection of exogenous, damp—heat and blood stagnation. The yah deficiency syndrome of spleen and kidney and the syndrome of turbid damp are less which mostly occur in the time of renal inadequacy. Its pathogenesis rule mostly developed from qi deficiency syndrome or yin deficiency syndrome to qi and yin deficiency syndrome, yan deficiency syndrome and with its development, its. clinical syndrome and pathological change would get worser and worser.