Interrelated Study Between TCM Syndromes And Common Laboratory Indicators In Lupus Nephritis

Objective:By analyzing the clinical case data of lupus nephritis patients,this paper aims to explore the correlation between the TCM syndrome types of LN and the common laboratory examination indexes and activity scores,so as to provide objective basis for the TCM syndrome differentiation and classification of LN,and improve the diagnosis and treatment level of integrated TCM and Western medicine.Methods:The hospitalized cases of lupus nephritis in Yunnan Traditional Chinese medicine hospital from 2009 to 2019 were collected,with a total of 99 cases and 142 visits,according to the inclusion criteria and exclusion criteria.We refer to the diagnosis standard of syndrome type of traditional Chinese medicine for syndrome differentiation,calculated the activity score according to the lupus activity score standard,selected the laboratory test results within three days after admission.After collecting and summarizing the above data,spss22.0 statistical software was used to analyze the correlation between TCM syndromes and common laboratory tests of lupus nephritis,and the analysis results were summarized,summarized and discussed.Results:1.The main syndromes of lupus nephritis in this area are Deficiency of liver-yin and kidney-yin(35.9%),followed by Deficiency of spleen-qi and kidney-qi(26.8%),Deficiency of both qi and Yin(26.1%),Excess of heat and toxin(5.6%),Deficiency of spleen-yang and kidney-yang(5.6%).Among them,26 cases(18.3%)were blood stasis syndrome and 21 cases(14.3%)were damp heat syndrome.2.There are differences in some laboratory indexes among TCM syndromes.The details are as follows:HDL-C,APOA1,C3 and CH50 of the group with Excess of heat and toxin were lower than those of the group with the Deficiency of liver-yin and kidney-yin,and HDL-C,APOA1 and UREA were lower than those of the group with the Deficiency of spleen-qi and kidney-qi.The ESR of the Deficiency of liver-yin and kidney-yin group was lower than the Excess of heat and toxin group,the positive rate of anti-P protein antibody was lower than that of the Deficiency of both Qi and Yin group,and the CHOL,LDL-C,APOB,LPa,UREA and ESR were lower than those of the Deficiency of spleen-qi and kidney-qi group.WBC,MONO,BASO,PLT,C3,C4,CH50 and PA in the Deficiency of both Qi and Yin group were lower than those in the Deficiency of liver-yin and kidney-yin group,while WBC,NEUT,PLT,PA,UREA,Cr,UA,CHOL,TG,LDL-C,APOB and LPA in the Deficiency of both Qi and Yin group were lower than those in the Deficiency of spleen-qi and kidney-qi group.TP,ALB,C3 and CH50 in the Deficiency of spleen-qi and kidney-qi group were lower than those in the Deficiency of liver-yin and kidney-yin group,and TP,ALB,GLB and Ig G were lower than those in the Deficiency of liver-yin and kidney-yin group.ESR and Ig G of the Deficiency of spleen-yang and kidney-yang group were lower than those of the Excess of heat and toxin group.ALB of blood stasis syndrome was lower than damp heat syndrome,TG,UREA,Cr,UA were higher than damp heat syndrome.All the above items had statistical difference(P < 0.05).3.Between the main syndromes of TCM,the SLE-DAI scores of the Deficiency of spleen-qi and kidney-qi group and the Excess of heat and toxin group were generally higher than those of the Deficiency of liver-yin and kidney-yin group(P < 0.05);the LACC scores of the Excess of heat and toxin group were generally higher than those of the Deficiency of liver-yin and kidney-yin group(P < 0.05).There was no significant difference in activity score between concurrent syndromes.Conclusion:1.The main syndromes of LN in this area are mainly Deficiency of liver-yin and kidney-yin,followed by Deficiency of both Qi and Yin and Deficiency of spleen-qi and kidney-qi,and less of Excess of heat and toxin and Deficiency of spleen-yang and kidney-yang.There is no significant difference in the distribution of two types of concurrent syndromes2.Some common laboratory examination indexes are related to TCM syndrome differentiation and classification,which can provide objective and scientific basis for TCM syndrome differentiation and treatment of lupus nephritis,and can effectively improve the level of diagnosis and treatment of the combination of Chinese and Western medicine,which has certain clinical significance and needs further study.