The Study Of Combined Internal And External Application Of Yigan Sanhao In Treatment Of Liver Fibrosis Resulted From Chronic Hepatitis B

【Objective】To observe the efficacy of combined internal and external application of Yigan sanhao (YGSH) in the treatment of Liver Fibrosis resulted from chronic Hepatitis B(CHB).【Methods】A total of 240 inpatients with CHB induced liver fibrosis were randomly divided into external application of YGSH group (n=58), internal application of YGSH group (n=62), integrated group (n=63) and control group (n=57). control group with the treatment of protected liver to fall the enzyme, group of external application: paste for external using + foundation treatment; group of internal application: taking medicine + foundation treatment; integrated group: paste for external using + taking medicine + foundation treatment. In the course of treatment, the paste of YGSH applied every day with 1 time, each time 4-12h, besides, stopped using it for 2days after 7 days; taking YGSH 1 preparation every day and dividing it for 2 times. 1 month is 1 course, examined each target, and usded it 3 courses continuously; Making a follow-up visit for 12 months, reexamined 1 time every 3 months. Observed the changes of the clinical symptoms, syndromes, liver function, five items of hepatitis B, HBV-DNA quota, 3 indexes of liver fibrosis, PGA parameters and hemodynamic changes, as well as the incidence of adverse effect and losing rate in a follow-up visit.【Results】The clinical symptoms were improved, especially in integrated group; In the aspects of improving liver function and PGA parameters,the differences of 4 groups were not to be obvious after imonth treatment, but after 3 months, there were significant differences among 4 groups (p＜0.01或p＜0.05) ,and the integrated group treatment was superior to the other three treatment. In the improvement of 3 indexes of liver fibrosis, each treatment group had significant differences after 3 months treatment (p＜0.01), and the treatment of integrated group compared with other groups, the difference had the significance (p＜0.01); Hemodynamic examination showed that the diameters of splenic and portal vein as well as the blood flow were decreased in all the groups, the difference had the significance (p＜0.01) ,especially significant in the integrated group, besides, the difference of D and Q had the significance in treatment and control group (p＜0.01) ,and there was not statistics significance in each treatment group (p＞0.05) ;A 12-month following-up demonstrated that combination of external and internal application had the most favorable effect. However, the anti-viral efficacy was not markedly different between the four groups.【Conclusion】The clinical efficacy of combined internal and external application of Yigan sanhao (YGSH) in the treatment of Liver Fibrosis resulted from chronic HepatitisB(CHB) is precisely, and it is superior to the single use. Three-month course is considered the most optimal, and long-term efficacy is better. It can improve the clinical symptoms, syndromes, liver function, 3 indexes of liver fibrosis, hemodynamic changes, and PGA parameters effectually, however, the anti-viral efficacy was not statistics significance between the four groups. The way of YGSH in the treatment of Liver Fibrosis resulted from CHB may be: recuperates the internal organs function inside, affects the liver from the multi-position through the collaterals osmosis, improves blood circulation of the liver directly and effectively, suppresses the proliferation of collagen, and promotes the degeneration of collagen, thus to block and reverse liver fibrosis.