Expression Of Survivin And VEGF In Colorectal Cancer Tissue And Their Clinical Significances

Objective To detect the expression of survivin and VEGF in colorectal cancer (CRC), and to evaluate the relationship between their expression and clinicopathologocal parameters, which will provide theoretical basis for the carcinogenesis, development, evaluation and therapy of colorectal cancer. Methods Immuno-histochemical technique was used to detect the expression of survivin and VEGF protein in 60 cases of colorectal cancer tissues and 30 cases of adjacent tissues, then to analysis the relationship between the expression and clinicopathological parameters. Results①The expression of survivin in CRC tissues were significantly higher than those in adjacent tissues (p<0.01).②The expression of VEGF in CRC tissues were significantly higher than those in adjacent tissues (p<0.01).③The expression of survivin were closely associated with lymphonode metastasis and differential degree of CRC (p<0.01), and were associated with invasive depth of CRC (p<0.05).④The expression of VEGF were closely associated with invasive depth,lymphonode metastasis and differential degree of CRC (p<0.01)⑤survivin expression was significantly positively correlated with VEGF expression (p<0.01). Conclusion①The expression of survivin in colorectal cancer shows a significant rise and a strong relationship with invasive depth,lymphonode metastasis and differential degree of CRC, which suggests that the high expression of survivin may play an key role in colorectal carcinogenesis and development.②The expression of VEGF in colorectal cancer shows a close correlation with invasion, lymphonode metastasis and differential degree of CRC, which suggests that the high expression of VEGF is closely related to colorectal carcinogenesis and development.③There exist a positive correlation of the positive expression between survivin and VEGF, which surggests VEGF may be a important factor in inducing the up-regulation of survivin.