The Protection Of Ramuli Cinnamomi And Glycyrrhizae Decoction And Its Extractive Composition To Rat Anoxemia Of Myocardium Douche Injury

Objective: The experiment extracted composition of Ramuli Cinnamomi and Glycyrrhizae Decoction by modern methods of Chinese pharmaceutical chemistry setting by anoxemia of myocardium douche injured animal models. By observe its pharmacodynamic and pharmacological action, we ascertained active components and foundamental mechanism of resisting experimental arrhythmia so that to provide reference for pharmacodynamic material foundation in pharmacology of Traditional Chinese Medcine and research of compatibility relation.Methods: On the base of rat anoxemia of myocardium douche injured models, we observed the effect of Ramuli Cinnamomi and Glycyrrhizae Decoction and its extractive composition on experimental anoxemia of myocardium douche injury. Contents of SOD,MDA,Ca²⁺ in cardiac muscle tissue and LDH,CK in blood serum can be measured.Results: 1. Ramuli Cinnamomi and Glycyrrhizae Decoction and its extractive composition of water and 30% ethanol can increase SOD activity and reduce MDA content in model rats' myocardial cells.2. It can depress the hoist of Ca²⁺ in cells induced by anoxemia of myocardium douche injury.3. It can reduce the contents of LDH and CK in blood serum. Comparing with model control group, results act significantly(P<0.05 or P<0.01).Conclusion: Ramuli Cinnamomi and Glycyrrhizae Decoction has complicating effects of resisting anoxemia of myocardium douche injury. At the same time, we almost ascertain that the active components for resisting anoxemia of myocardium douche injury is composition of water and 30% ethanol. In this experiment, we established the foundation of investigating active components of Ramuli Cinnamomi and Glycyrrhizae Decoction deeply.