| Objective To study the role of co-detections of 4 tumor markers CA125,CA199,CEA,TSGF in differential diagnosis of benign and malignant pleural effusion . Methods The levels of CA125,CA199,CEA,TSGF in serum and pleural effusion were detected by ELISA and colorimetry, the sensitivity and the specifity of the the single tumor marker and tumor markers combined assay were counted . The diagnostic value of combined assay of these four tumor markers was evaluated. Results Serum and pleural fluid Levels of CA125,CA199,CEA,TSGF in patients with malignant effusion were significantly higher than those patients in benign pleural effusions(P<0.01). pleural fluid levels of CA125, CA199,CEA,TSGF in patients with malignant effusion were significantly higher than serum levels of those (P< 0.05) . The sensitivity of the combined testing of three, four tumor markers in both serum and pleural fluid were higher than those of the single tumor marker(P<0.01 ). The combined testing of four tumor markers in serum increased the diagnostic sensitivity to 94.4%, contrast with the sensitivity of CA125+CA199+CEA,CA125 +CEA+TSGF and CA125+CA199+TSGF in serum(P<0.05).while the specifity of those was 83.5%.declining little (P>0.05) ,contrast with the specifity of the combined testing of three tumor markers. Four tumor markers in pleural effusion increased the diagnostic sensitivity to 95.8 %, contrast with the sensitivity of CA125+CA199+CEA, CA125+CA199+TSGF in pleural fluid (P<0.05) . while the specifity of those was 82.3%.not declining significantly (P> 0.05) ,contrast with the specifity of the combined testing of three tumor markers.Conclusions The combined assay of four tumor markers CA125,CA199,CEA,TSGF in serum and pleural effusion increased the diagnostic sensitivity, while the specifity of those was not declining significantly .The co-detections of four tumor markers in serum and pleural effusion show great values in the diagnosis and differential diagnosis for malignant and benign pleural effusion.
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