Relationship Of Serum Adiponectin With High Sensitivity Reactive Protein And Insulin Resistance In Patients With Essential Hypertension

ObjectiveTo explore the serum adiponectin (APN) concentrations in patients with essential hypertension, and the relationships among adiponectin and blood pressure, body mass index (BMI), insulin, insulin resistance index (IRI) and high sensitivity C-reactive protein (hs-CRP).Methods65 hypertensive patients who all coincided with 1999 WHO diagnostic standard were enrolled, secondary hypertension, diabetes mellitus, coronary heart disease, heart failure, renal failure, cerebrovascular disease patients were excluded. And 40 healthy subjects were collected as control group. All of them were measured height, weight and waist circumference (WC), calculated BMI. And they were taken fasting blood samples for measurements of plasma glucose, plasma lipids, insulin, hs-CRP (ELISA), and adiponectin (ELISA). The relation among adiponectin, hs-CRP and IRI was analyzed.Results1. The concentrations of adiponectin in hypertensive group were significant lower than those in the control group[(10.30±0.93)ug/ml VS (12.83±1.66)ug/ml), P<0.01]. The control group and hypertensive group were divided into two sub-group that were normal weight group and overweight group respectively. ANOVA analysis suggested that adiponectin were significant different among four subgroups. LSD analysis suggested that four subgroups had significant difference one another, excluding hypertensive subgroups (P<0.05).2. In control group, the concentrations of adiponectin in female were significant higher than those in male[(13.51±1.28)ug/ml VS(12.15±1.75)ug/ml, P<0.05].3. Pearson relation analysis showed that: adiponectin levels were negatively correlated with BMI(r =-0.399, P<0.05), WC (r =-0.340, P<0.05), FINS (r=-0.317, P<0.01) and positively correlated with HDL-C (r =0.363, P <0.05) in control group. Adiponectin levels were negatively correlated with SBP (r = -0.304, P<0.05), BMI(r =-0.496,P<0.01), WC (r =-0.539, P<0.01), TG (r =-0.320, P<0.05), FINS(r =-0.291, P<0.05) ,IRI (r =-0.334, P<0.05) , hs-CRP (r =-0.319, P<0.05), and positively correlated with HDL-C (r =0.306, P <0.05) in hypertensive group.4. The concentrations of hs-CRP and IRI in hypertensive group were significant higher than those in control group[(2.68±0.78)mg/L VS (1.67±0.04)mg/L, (1.53±0.62)VS(1.27±0.29), P<0.01]. The hs-CRP levels positively correlated with IRI in hypertensive group (r=0.368, P<0.05).5. Multiple regression analysis showed that SBP, WC, HDL-C, hs-CRP were independent factors to adiponectin levels in hypertensive group, meanwhile BMI and FINS were independent factors to adiponectin levels in control group.Conclusions1. The lower adiponectin level in hypertensive patients is associated with blood pressure and maybe promote the development of hypertension.2 Increased hs-CRP concentration and IRI play a role in the development of hypertension. The association among adiponectin, hs-CRP, IRI and many clinical factors indicates that adiponectin, hs-CRP, IRI can be taken as the referring index for predicting and intertenting hypertension.