Related Risky Factor Of Cerebral Artery Stenosis In Patients With Ischemic Cerebrovascular Disease

Objective:To explore the distribution and related risky factors of intra and extracranial artery stenosis in patients with ischemic cerebrovascular diseases.Methods:Three hundred and forty-seven patients with ischemic cerebrovasculardisease were examed by using DSA who were divided into young-middeaged and old aged group by different age as well as the cerebrova-scularstenosis(CVS)and non-stenosis (CVNS)group. Statistical analysis wasused to evaluate the incidence, the degree, the distribution and risk factorsof intra and extra cranial artery stenosis.Results:The prevalence of intra and extra cranial artery stenosis in ischemiccerebrovascular disease group is 152/347(43.8%), of which, thefrequency of stenosis of intracranial artery was 80/152(52.6%), thefrequency of stenosis of extracranial artery was 21/152(13.8%), and thefrequency of stenosis of intracranial and extracranial artery was51/152(33.6%). The degree of intra and extra cranial artery stenosis waspositively correlatedtoage (r_s=0.156, P＜0.05). Hypertension (HBP),diabetes(DB), homocysteic(HCY), totalcholesterol(TC), fibrinogen(FIB) in CVS group were significantly higher than that in CVNSgroup(P＜0.05).Conclusions:In patients with ischemic cerebrovascular disease the incidence ofstenosis of intracranial artery is significantly higher than that of extracraniial artery stenosis.The degree of cerebral artery stenosis varies with age.The level of HBP. DB, HCY, TC, FIB was positively correlated to therate of carotid artery stenosis, while HCY and DB were independent riskfactors of cranial artery stenosis. Objective:To study the efficacy and safety of endovascular stenting in thetreatment of ischemic cerebral angiopathy.MethodsAll 14 patients with ischemic cerebrovascular disease were proved＞70% stenosis in intra and extra cranial artery by DSA from April,2006 to December, 2006. Of which, 11 with stenosis at the beginningof left internal carotid, 2 with stenosis at the beginning of the dominantvertebral artery, one patient with stenosis of both the beginning of leftinternal carotid and the dominant vertebral artery. Using theimprovement seldinger technique to puncture femoral artery, 12self-expandable stentts and 3 balloon-expandable stents were implantedin the stenosis segment. The cerebral protection device were used in all12 Carotid artery stenosis.Results:All 14 cases were successfully treated with stents implantation, theresidual stenosis was less than 10%. The bradycardia during operation intwo cases and sequential hypotension in the one case with internal carotidstenosis were respectively corrected with atropine and dopamine. No other serious complications occurred. Follow-up for 3 months neither anysymptom nor re-narrowed appeared in all 14 patients.Conclusions:Endovascular stenting may be a safe and preferable choice of treat-ment for severe cerebral arterial stenosis.