Associative Analysis Between The SNP Polymorphism Of IL1RAPL1 Gene With Children's Mental Retardation And Intelligence In QinBa Mountain Area

In order to investigate the possibility of the association of IL1RAPL1 gene with children's mental retardation and intelligence in QinBa mountain area, we use three SNPs rs12847959, rs6526806 and rs6630762 as genetic marker to do the case-control association study for children in QinBa mountain. After analysis with various method, such as PCR-SSCP, Agarose GE, PAGE and DNA sequencing, the genotype frequency of rs12847959 in all children was in accordance with Hardy-Weinberg equilibrium. The associative analysis between the polymorphism of rs12847959 and children's mental retardation showed, for female and male sample, there is no significant association between mental retardation group and control group, and there are similar result between border group and control group. And there is no significant association to be found between the polymorphism of rs12847959 and the different level of children's intelligence. The rs6526806 was in accordance with Hardy-Weinberg equilibrium. In the two samples, there is no significant association between mental retardation group and control group, and the same result between border group and control group. And, there is no significant association to be found between the polymorphism of rs6526806 and the different level of children's intelligence in the two samples. We used the technology of PCR-SSCP to analyses the polymorphism of the rs6630762, and we don't find any polymorphism. The results suggest that: (1) rs12847959 has no association with children's intelligence in QinBa mountain area. (2)IL1RAPL1's rs6526806 has no association with children's mental retardation, the possible reason is that rs6526806's polymorphism couldn't influences the amino acid's transcription.