TO Approach The Distinct Phenotype Of Distribution Regularity Of The Symptom Of The Traditional Chinese Medicine Of Polycystic Ovary Syndrome

Background of theoryPolycystic Ovary Syndrome is the most frequent kinds of endocrinedisturbance disease of child-bearing period women, the material of womenanovulia infertility. The inception rate is 5-10％in child-bearing period women,The inception rates of PCOS are 9％and 4％in the research discovery of Greeceand American. The clinical manifestation, the change of biochemistry parameterand pathogenesis have elevheterogenicity of the primary disease, all thesebecome the most multiple research warm spots in department of gynecologyhemisphere. The archappearances of clinical symptom are irregular menses(delayedmenorrhea,oligomenorrhea,amenorrhea),infertility,adipositas,hairness,melano thorn hull, etc. However, its mechanism has not yet been wellknown. With the development of technology, it has made a great achievementin its therapy in modern western medicine, but it still lacks special therapymethods. Both medicine therapy and surgery therapy have affect on the lifequality of women, neither can cure it essentially and eliminate the symptomspermanently. All of these contribute to its recrudescence. A great progressin improving the symptoms and amending the side-effects has been made alongwith the fast development of the combination of TCM and western medicine. Alot of literatures demonstrate that at present the research quantity of thetypes of TCM syndromes in PCOS is less. It is occasionally to see the geneticresearch of PCOS. The research of genealogy inheritance gets invariably resultup to now, but we need a more large sample research because there is noascertainment. There are no differentiation of symptoms and signs of TCM to analyze the symptom appearance of the corpulent and discorpulent,no largesample research to approach the disposition rule of the type of the syndromeof PCOS. So it has profound meanings to make a research on the changed ruleof the different phenotypic correlation parameter of PCOS and the possibleassociation with the classification of TCM syndrome, thereby to set up thestatistical model of the primary disease and phys chem. parameter and to offerscientific basis for primary disease the TCM curative effect evaluation.ObjectiveTo make a research on the changed rule of the different phenotypiccorrelation parameter of PCOS and the possible association with theclassification of TCM syndrome, thereby to set up the statistical model ofthe primary disease and phys chem. parameter and to offer scientific basisfor primary disease the TCM curative effect evaluation.MethodsUsing the designed information-collecting table,clinical case directobservation method,clinical epidemiology study method,mathematicalstatistics method. Then make the normalizational research on the distinctphenotype symptom of traditional Chinese medicine of PCOS, summary andinduction the distributional feature on the distinct phenotype symptom oftraditional Chinese medicine of PCOS.Results1,The study showed that the syndrome of renal deficiency and blood stasiswas the most common syndrome,the next was the syndrome of splenic astheniaand phlegmatic hygrosis, the thirdly was the syndrome of asdthenicsplenonephro-yang, the quartus was the syndrome of deficiency of kidney-YIN.2,The correlation of endocrine secretion test and PCOS: the FSH with thesyndrome of asdthenic splenonephro-yang and the syndrome of stagnation ofliver-QI and blood-heat were positive correlations, the danger coefficiectswere partly 1.636, 1.824, the LH with the syndrome of renal deficiency andblood stasis were positive correlations, the danger coefficiects was 1.086;the PRL with the syndrome of qi-stagnancy and blood stasis were positivecorrelations, the danger coefficiects was 3.068; the E2 with the syndrome ofqi-stagnancy and blood stasis were positive correlations, the dangercoefficiects was 17.424; the PRG with the syndrome of liver-QI and blood-heatwere positive correlations, the danger coefficiects was 1.366. 3,The correlation of insulin test and PCOS: the INS with the syndrome of splenicasthenia and phlegmatic hygrosis and the syndrome of stagnation of liver-QIand blood-heat were positive correlations, the danger coefficiects were partly1.132, 1.211; the empty stomach blood GLU with the syndrome of splenic astheniaand phlegmatic hygrosis were positive correlations, the danger coefficiectswas 2.685.4,The correlation of other correlation factors and PCOS: the hairness scorewith the syndrome of splenic asthenia and phlegmatic hygrosis were positivecorrelations, the danger coefficiects was1.200: the WHR with the syndrome ofsplenic asthenia and phlegmatic hygrosis were positive correlations, thedanger coefficiects was2.424: the BMI with the syndrome of splenic astheniaand phlegmatic hygrosis and the syndrome of stagnation of liver-QI andblood-heat were positive correlations, the danger coefficiects were partly1.075, 1.735; the acne score with the syndrome of stagnation of liver-QI andblood-heat were positive correlations, the danger coefficiects was 2.533;the maternal inheritance with the syndrome of splenic asthenia and phlegmatichygrosis were positive correlations, the danger coefficiects was2.819.5,The difference of endocrine alteration among the each syndrome: Thedifference of LH/FSH＞3 amongthe groups of splenic asthenia and phlegmatichygrosis and negative splenic asthenia and phlegmatic hygrosis, the groupsof asdthenic splenonephro-yang and negative asdthenic splenonephro-yang wassignificant(P＜0.05),so it can speak that it more frequently to see clinicallyasdthenic splenonephro-yang when LH/FSH＞3.ConclusionThe study showed that the syndrome of renal deficiency and blood stasis wasthe most common syndrome,the next was the syndrome of splenic asthenia andphlegmatic hygrosis, the thirdly was the syndrome of asdthenicsplenonephro-yang, the quartus was the syndrome of deficiency of kidney-YIN.The FSH and LH of endocrine secretion test with the syndrome of renal deficiencywere positive correlations, The PRLand E2 with the syndrome of qi-stagnancyand blood stasis were positive correlations. The INS and the empty stomach bloodGLU with the syndrome of splenic asthenia and phlegmatic hygrosis were positivecorrelations, the acne score with the syndrome of stagnation of liver-QI andblood-heat were positive correlations, the maternal inheritance with thesyndrome of splenic asthenia and phlegmatic hygrosis were positive correlations. And there was no significant difference of paternal inheritancefactors among groups. It more frequently to see clinically the syndrome ofsplenic asthenia and phlegmatic hygrosis and the syndrome of asdthenicsplenonephro-yang when LH/FSH＞3.