Clinical Research On Efficacy Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease (AECOPD) With Tan Re Qing Injection, And Its Effect On Tunlor Necrosis Factor-α (TNF-α), Interleukin-8 (IL-8) In The Peripheral Blood

OBJECTIVEThe aim of the study was to assess the effect of Tan Re Qing Injection on AECOPD by analyzing the symptom, sign, blood gas analysis, TNF-α,IL-8 in the peripheral blood.METHOD60 AECOPD patients (stageⅠ～Ⅱ) with retention of Phlegm and Heat Syndrome in the Lung were randomly assigned to the treating group or to the control group. The treating group accepted conventional therapy of the western medicine(Controllability oxygen treatment, bronchodilators, antibiotic, expectorants)plus Tan Re Qing Injection, while the control group purely accepted conventional therapy of the western medicine. The course was 10 days. The clinical symptoms and sign, blood gas analysis, the level of TNF-α,IL-8 in the peripheral blood were observed and compared after 10 days.RESULTS1. The management of Tan Re Qing Injection could improve the clinical symptoms and sign of COPD patients. The clinical symptoms and sign of both group have significant difference after ten-day treatment compared with the clinical symptoms and sign before the treatment (p＜0. 05或p＜0. 01). The clinical symptoms and sign of the treating group was better than the control group with significant difference (p＜0. 05或p＜0. 01) after the treatment, which showed the management of the treating group is better.2. The management of Tan Re Qing Injection could remedy the state of anoxia and carbon dioxide retention. PaO₂ and PaCO₂ of each group have significant difference (p＜0. 05) after the treatment compared with pre-treatment, that showed the managements of both groups could improve PaO₂ and reduce PaCO₂. After the treatment, PaO₂ and PaCO₂ of the treating group is better than the control group, with significant difference(p＜0. 05)3. The management of Tan Re Qing Injection could reduce inflammatory factors——TNF-α,L-8 in the peripheral blood. TNF-α, IL-8 in the peripheral blood of both groups reduce, showing significant difference (p＜0. 05), this show that both managements of the two groups could reduce TNF-α, IL-8. And TNF-α, IL-8 reduce more greatly in the treating group than the control grou, with significant difference (p＜0. 05),which shows that the effect of the treating group on reducing TNF-α, IL-8 is more significant than the control group.CONCLUSIONSThe management of the Tan Re Qing Injection can help AECOPD patients, it can improve the clinical symptoms and sign, remedy the state of anoxia and carbon dioxide retention, reduce inflammatory factors——TNF-α,IL-8 in the peripheral blood .