Clinical Research On Modified XueFu ZhuYu Decoction In The Treament Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease (AECOPD)

Objective:To observe the curative effeet on AECOPD with the Modified XueFu ZhuYu Decoction on clinical symptoms and sign, blood gas analysis, ET with AECOPD patients.Method:Sixty hospitalized AECOPD patients (StageⅠ—Ⅱ) with accumulation of phlegm and blood stasis syndrome in the lung in TCM are randomly divided into two groups, the trial group and the control group. The patients of trial group take the Chinese medicine decoctions which is Modified XueFu ZhuYu Decoction, and simultaneously accept conventional therapy of the western medicine same as the control group (controllability oxygen treatment, bronchodilators, antibiotic, expectorants). The period of treatment is 10 days. To compare the result of two groups by analyzing clinical symptom and sign, blood gas analysis, ET.Result:1. Clinical symptom and sign:After the treatment, melioration of clinical symptom and sign in both groups have significant difference. Compared with the control group, melioration of the trial group, such as phlegm, dyspnea, chest distress, rhonchus, appetite is greater, showing significant difference. The above result show that therapy of two groups both can help AECOPD, and the trial group is better than the control group.2. Blood gas analysis:PaO2 and PaCO2 of each group have significant difference(P<0.05) after 10-day treatment compared with pre-treatment that showed both managements of the two groups could improve PaO2 and reduce PaC02. PaO2and PaCO2 of the treating group have significant difference (P<0.05) after 10-day treatment compared with the control group that showed the management of the treating group was better than the control group in PaO2 and PaCO2.3. ET:The level of plasma ET of each group have significant difference(P<0.01)after 10-day treatment compared with pre-treatment that showed both managements of the two groups could degrade the level of plasma ET. The level of plasma ET of the treating group is lowered, this is preferable to the control group(P<0.01).Conclusion:The management of Modified XueFu ZhuYu Decoction could improve the clinical symptoms and sign, remedy the state of anoxia and carbon dioxide retention, degrade the level of plasma ET so as to accelerate rehabilitation of AECOPD patiens.