Clinical Significance Of Mutidruge Resistance Gene Expression In Colorectal Carcinoma

Objective To explore the relationship between expression of MDR1 gene in human colorectalcarcinoma and clinicopathological changesMethods From Sept 2004 to July 2006, a total of 93 consecutive patients with colorectal carcinomawere recruited, and MDR1 mRNA were detected by RT-PCR. Fresh tumor tissues weresurgically resected without chemotherapy before operation.Results The positive rate of MDR1 mRNA was 37.63%. The mdrl expression was not significantlycorrelated with age or sex of patients, tumor size, histologic types, lymph nodeinvolvment or Dukes stage.Conclusions Because of high expressive level of MDR1 gene in untreated colorectal carcinoma,appropriate chemotherapeutic regimen should be individually chosen for colorectalcarcinoma. The expression of MDR1 gene in untreated cancer was independent ofmorphologic prognostic indexes without correlation between MDR1 gene expression andmorphological indexes.