Study On Relationship Between Polymorphism Of The Estrogen Receptor A Gene And Osteoporosis

Objective To investigate the relationship between polymorphism of the estrogen receptora(ESRa)gene and osteoporosis in Shandong peninsula Han people postmenopausal women. Methods In 106 postmenopausal women with osteoporosis, aged 50～86 years(average 68 years)and 82 postmenopausal women without osteoporosis, aged 47～77 years(average 56 years), bone mineral density(BMD) was measured by dual energy X-ray absorptiometry. XbaⅠand PvuⅡrestriction fragment length polymorphism (RFLP) of ESRawere analysed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The relationship between polymorphism of the estrogen receptor a gene and osteoporosis was evaluated. The RFLP was represented as Xx (XbaⅠ) and Pp (PvuⅡ). Results Using x~2 analysis, we concluded that there was no difference in the distribution of genotype and allele frequency between osteoporosis group and control group (P＞0.05). There was no statistical significance among "Xx,xx,XX" genotype (P＞0.05) and no statistical significance between "x" and "X" allelic genes(P＞0.05). There was no statistical significance among "Pp,pp,PP" genotype (P＞0.05) and no statistical significance between "p" and "P" allelic genes (P＞0.05). Conclusion The results suggested that there is no association between ESRagene XbaⅠ,PvuⅡRFLP and osteoporosis in Shandong peninsula postmenopausal women.