Therapeutic Effect And Prognostic Analysis Of Radiofrequency Ablation Therapy For 209 Liver Cancer

Objective: To investigate the survival and the prognostic factorsaffecting outcome in Radiofrequency ablation of liver cancer, so thatmeasures can be taken in advance to improve the therapeutic effect.Meanwhile, sum up the complications of RFA to evaluate the safety ofthis therapy.Methods: The clinical data of 209 patients with liver cancer, whichwere not the surgery candidates, treated by percutaneous andintraoperative RFA in Xiangya Hospital of CSU between August 2000and December 2006, were analysed retrospectively. 15 factors, whichpotentially affected the survival, were chosen to be analysed in univariateand multivariate . Univariate analyses used Kaplan-Meier model andLog-rank test, while multivariate analyses used COX regression model.Results: The survival rates of RFA for PHC at 1 year, 2 year, 3year and 5 year were 80.5ï¼…, 67.4ï¼…, 49.1ï¼…and 32.7ï¼…,of which,thesurvival rates of small hepatocellular carcinoma that under 3cm at 1,2,3and 5 year achieved 91.7ï¼…,81.2ï¼…,60.5ï¼…and 40.4ï¼…; the survival rateof MCL at 1 year achieved 54.0ï¼….Using univariate analyses,15 potentialfactors were analyzed and in PHC 8 of them were found significant forsurvival.These 8 factors were Child-Pugh grade, cirrhosis or not, AFPvalue before first RF, diameter of mass, whether near to great vessels, times of RFA, having other therapys or not, first treatment or treatmentfor recurrence; while MCL only were Child-Pugh grade and times ofRFA.The 8 factors mentioned above in PHC were further analyzed bymultivariate model and 3 of them were identified as prognostic factors forsurvival. These 3 factors included Child-Pugh grade, AFP value beforefirst RF and having other therapys or not; while MCL only includeChild-Pugh grade.The incidence rate of serious complication was7.2ï¼….No death related to the therapy.Conclusion- RFA is a safe and effective minimal-invasive treatmentfor patients with liver cancer, especially for small hepatocellularcarcinoma, which can achieve the therapeutic effect equal to operation.The prognostic factors on outcome in Radio-frequency ablation of PHCwere Child-Pugh grade, AFP value before first RF and having othertherapys or not, while MCL was Child-Pugh grade. If we choose properpatient, improve its liver function before operations, meanwhile, usingother therapys together, RFA can get a better effect.