Expressions Of CEACAM1 And Its Relationship With Angiogenesis In Lung Cancer

Objective:To investigate the expressions of carcinoembryonic antigen-related celladhesion molecule 1(CEACAM1)in Lung Cancer, its relationship with theexpression of vascular endothelial growth factor (VEGF) and microvesseldensity(MVD), and explore the role of CEACAM1 in angiogenesis in lungcancer.Methods:expressions of CEACAM1 and VEGF and MVD in 50 specimens oflung cancer tissues were detected by immunohistochemistry, and therelationship with histological type, differentiation, TNM staging and lymphnode metastasis were analyzed.Results:1. Positive rate of CEACAM1 was significantly higher in Lung Cancerthan in normal lung tissues (98.00% vs. 10%a, x~2=15.69, P＜0.01).2. Positive rate of VEGF was significantly higher in Lung Cancer thanin normal lung tissues (92.00% vs. 40.00%a, x~2=5.09, P＜0.05).3. MVD was significantly higher in Lung Cancer than in normal lungtissues(26.28±7.75vs. 10.30±1.71, t=5.57, P＜0.01).4. Statistical analysis was done to show a positive correlation betweenCEACAM1 expression and VEGF expression (r=0.59, P＜0.01). Statisticalanalysis was done to show a positive correlation between CEACAM1expression and MVD (r=0.44, P＜0.01).5. CEACAM1 expression was positively correlated with TNMstage of Lung Cancer (r=0.34, P＜0.05)and negatively correlated withdifferentiation of tumor cell of Lung Cancer by Statistical analysis ((r=-0.43, P＜0.01), but not correlated with histological type and lymph nodemetastasis.Conclusion:1. CEACAM1 is overexpressed in Lung Cancer, indicating that it mightplay an important role in growth and metastasis of lung canaer.2. The expression of CEACAM1 show positive correlation with theexpression of VEGF and MVD, which suggests CEACAM1 might takes partin angiogenesis of lung cancer.