Changes Of Concentration Of Plasm High Sensitivity C-reactive Protein And Interleukin-6 In Patients With Atrial Fibrillation In Various Clinical State.

Objective: To explore the correlation between various clinical state and inflammation in patients with atrial fibrillation( Af )by investigate changes of concentration of plasm high sensitivity C-reactive protein(hs-CRP) and interleuki-6 (IL-6) in patients with Af.Methods: 60 patients who were diagnosed as Af were entered and were compared with normal control group (n=20), patients with Af were divided into two groups:paroxysmal Af (n=18)and no paroxysmal Af (n=42) group according to spontaneously termination, no paroxysmal Af group were divided into various subgroups according to left atrial diameter(LAD≤40mm, LAD>40mm),age(<70y,≥70y),left ventricle eject fraction(LVEF < 50%, LVEF≥50%),respectively. Enzynle-linked immunonsorbent assay(ELISA) methods were used to measure plasma hs-CRP and IL-6 levels in 60 patients with Af and in normal control group,statisticl evaluation was performed with SPSS 12.0 software.Results: The plasm Hs-CRP and IL-6 level of paroxysmal Af and no paroxysmal Af group were significantly higher than that of normal control group (P<0.001, respectively), the plasm hs-CRP and IL-6 levels in patients with no paroxysmal Af group were higher than that in patients with paroxysmal Af(P<0.05, P<0.001, respectively). The plasm hs-CRP and IL-6 levels of LAD>40mm in patients with no paroxysmal Af were significantly higher than that in subset of LAD≤40mm (P<0.001, respectively), The plasm hs-CRP and IL-6 levels in subset of age≥70y in patients with no paroxysmal Af was higher than that in subset of age 70y . No significant changes of their levels were found between LVEF<50% and LVEF≥50% group in patients with no paroxysmal Af after adjusted by covariance analysis.Conclusion: 1 The plasm hs-CRP and IL-6 levels in patients with Af are significantly elevated than that in normal control group, The plasm hs-CRP and IL-6 levels in patients with no paroxysmal Af are higher than that in patients with paroxysmal Af. The results indicate that inflammation in Af patients may play an important role in the initiating and sustaining Af.2 Not only the plasm hs-CRP and IL-6 levels in subset of LAD>40mm, age≥70y in patients without no paroxysmal Af are significantly elevated,but also there are positive correlation between the plasm hs-CRP , IL-6 levels and LAD , and there are positive correlation between the plasm hs-CRP and age. Thus,this study indicates that the inflammatory reaction may promote the occurrence and progression of atrial fibrillation by affect atrial remodeling.