Correlative Study On Relationship Between Serum High-sensitive C-reactive Protein And Left Atrial Diameter And Atrial Fibrillation

BackgroundsAtrial fibrillation (AF) is the incidence of an aging society increases year after year, seriously affecting the quality of human life, increased social burden. As we all know, AF's predictors included:age, hypertension, valvular disease, myocardial infarction, diabetes, congestive heart failure and other diseases. However, some patients with AF without underlying disease, we call the "lone AF", How to assess the risk factors for lone AF and predict the occurrence of AF, which is the prevention and treatment of AF have significant value.In recent years, many studies have shown that the generation of inflammation in AF, may play an important role in maintenance and renewal.The C-reactive protein (CRP) as a typical acute phase proteins is considered a non-specific indicators of inflammatory response, for cardiovascular and cerebrovascular disease is an independent risk factor. Serum CRP in patients with AF was significantly higher than non-AF patients, CRP may be involved in atrial remodeling and play an important role in maintaining. This study supplement the existing knowledge of AF's mechanism and risk factors, suggesting that we using the most effective therapy in the prevention and treatment of AF, and completing to cure AF, reduce relapse, so that patients benefit from the treatment of AF.ObjectiveTo detect serum levels of high sensitive C-reactive protein (hs-CRP) and left atrial diameter (LAD) in patients with AF. To explore the relationship between hs-CRP,LAD in patients with AF, and asses the risk factors of AF.Methods50 patients who hospitalized in the First Affiliated Hospital of Zhengzhou University, Department of Cardiology, from November 2009 to May 2010 were included in this study. According to the American Heart Association/American Heart Association/European Society of Cardiology (ACC/AHA/ESC) 2006 guidelines issued for treatment of atrial fibrillation.The AF group was divided into 18 cases of paroxysmal atrial fibrillation; 12 cases patients of persistent AF group (including permanent AF) and normal control group of 20 cases.All patients had serum hs-CRP, WBC counts, serum biochemistry, echocardiography. And to analyse the correlation between serum hs-CRP, WBC counts, BMI with LAD.Results1. The serum hs-CRP levels of perisisent AF is higher than both paroxysmal AF(P=0.049) and normal controls (P<0.001), paroxysmal AF is higher than normal controls(P=0.037), both had statistical significance.2. The LAD of perisisent AF is higher than paroxysmal AF(P=0.019) and normal controls(P<0.001), paroxysmal AF is higher than normal controls(P=0.013), both had statistical significance.3. The BMI of perisisent AF is significantly higher than normal controls (P<0.001), paroxysmal AF is higher than normal controls(P=0.019), both had statistical significance; But compared perisisent AF with paroxysmal AF(P=0.143), had no statistical significance.4. The WBC counts of perisisent AF is significantly higher than normal controls(P<0.001), paroxysmal AF is higher than normal controls(P=0.016), both had statistical significance; But compared perisisent AF with paroxysmal AF(P=0.104), had no statistical significance.5. Correlation analysis showed that, serum hs-CRP levels, WBC counts and BMI was positive correlation with the LAD.Conclusion1. The study find that hs-CRP levels were significantly increased in patients with AF, and associated with the type of AF, inflammation may be involved in the occurrence and maintenance of AF.2. The study find that serum hs-CRP and LAD was positively correlated in patients with AF, both was significantly higher in patients with persistent AF.3. The study find that WBC counts and BMI was increased in patients with AF but not associated with the type of AF, both may be the risk factor forAF.