| Background: The etiopathogenisis of Tourette's syndrome(TS) remains unknouwn so far. Autoimmune mechanisms have been supposed to be associated with TS. Further researches need to be down to investigate how the immune factors react in the pathomechanisms of TS. Objective: To explore the associations between streptococcal infection and TS and how the immune factors react, and effect of immunomodulator in TS. Method: ASO, T lymphocyte subgroups, NKC, IL-6, IL-8 and TNF-αin peripheral blood were measured in 58 children with TS and 128 healthy children. Children with abnormal immune functions in TS group were divided randomly into two groups and were treated respectively by simple immunomodulator and by dopaminergic receptor antagonists while using immunomodulator. Result:①The positive rate of ASO in TS group was higher than that of control (P＜0.05), and in TS＋ADHD group was higher than that of TS-only group (P＜0.05);②The ASO positive group in children with TS had lower level of CD4+ as compared with the negative group (P＜0.05), and had lower lever of IL-6 and IL-8 as compared with control (P＜0.01);③Compared with control, the levels of CD3+, CD4+, CD4+/CD8+ in TS group were depressed(P＜0.05), IL-6, IL-8 were depressed (P＜0.01) and NKC and TNF-αwere increased (P＜0.05 and P＜0.01);④There were significant positive correlations among IL-6, IL-8 and TNF-α(P＜0.01);⑤After 8W of treatment, the level of IL-8 was higher in the group treated by simple immunomodulator than that of by dopaminergic receptor antagonists while using immunomodulator (P＜0.05)Conclusion:②Group A streptococcal infection may be associated with TS;②Streptococcal infection is responding in the change of the cellular immunity, the disequilibrium of Th1/Th2 or cytokine network may play a role in the pathomechanisms of TS.③Simple immunotherapy may be effective in treating TS triggered by streptococcal infections.
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